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Prostate cancer is the second leading cause of death among American males, but when caught early, prostate cancer has a 90% cure rate. According to Dr. David Samadi, Chief, Division of Robotics and Minimally Invasive Surgery, Department of Urology, at Mount Sinai Medical Center, “The key to fighting prostate cancer is not to wait until there are warning signs, because by then it may be too late.

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UroToday.com - In the online issue of Urology, Dr. Antonopoulos and colleagues from Brazil present an approach for surgical treatment of localized prostate cancer (CaP) in men who have already undergone renal transplantation. The protocol was established between August 2004 and November 2007. During that time period 8 men who had undergone renal transplantation were diagnosed with CaP. The cutoff for PSA used to biopsy was 2.

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ORLANDO, FL (UroToday.com) - There were many interesting presentations this year. Highlights included PSA follow-up protocols after radical prostatectomy, predictors of incontinence after prostate surgery, adjuvant radiation therapy, and high-intensity frequency ultrasound for the treatment of focal prostate cancer.

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UroToday.com - Cryotherapy has benefited from many technical advances in recent years. “Third generation” delivery systems have significantly decreased the rate of complications resulting in a renewed interest in cyrotherapy for treatment of localized prostate cancer. Unfortunately, PSA control still remains suboptimal. 5yr PSA failure rates range from 60-87% for low risk patients and are even higher for intermediate and high risk patients.

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ORLANDO, FL (UroToday.com) - In this interesting study, Dr. Janet Colli and colleagues evaluated whether prostate cancer (CaP) death rates correlated with PSA screening and with the number of urologists per unit of population. In an attempt to account for access to care and socioeconomic status, investigators performed a multivariate analysis controlling for median family income, socioeconomic status, degree of urbanization, and health insurance status.

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ORLANDO, FL (UroToday.com) - In a certain proportion of prostate cancers, the prostate-specific androgen-regulated gene TMPRSS2 is fused with the gene for the transcription factor ERG. This gene fusion product may have prognostic significance in men with the CaP; however, the exact prevalence of the genetic abnormality is debated.

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UroToday.com - In the online version of the BJU International, Dr. Liss and colleagues assess the risk factors associated with a positive surgical margin (PSM) that can occur during robotic radical prostatectomy (RARP). Between 2003 and 2007, 216 consecutive patients underwent RARP by one surgeon. Clinical and pathologic characteristics were assessed in univariate and multivariate analysis.

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ORLANDO, FL (UroToday.com) - Dr. Matthias Heck, et al. examined the occurrence of Peyronie’s disease (PD) after radical prostatectomy. The incidence of PD in the general population is estimated to be between 3-9%. A retrospective review of 589 patients undergoing radical prostatectomy was performed to examine the incidence of PD in this population with a mean age of 62 years. Results showed that 102/589 developed PD post prostatectomy for an incidence of 17%.

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ORLANDO, FL (UroToday.com) - Highlights of the advance prostate cancer session included; effectiveness of salvage radiation therapy for a rising PSA after radical prostatectomy, role of an extended lymph node dissection, dutesteride for rising PSA, use of anti-PSMA monoclonal antibodies for hormone-refractory prostate cancer, and long-term side effects of androgen deprivation. Abstract 522 evaluated men with a rising PSA after radical prostatectomy.

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ORLANDO, FL (UroToday.com) - Although reduction in prostate cancer mortality rates is important, it is necessary to consider the effects of prostate cancer screening and treatment on patient quality of life. Potential gains in survival could be more than offset decrements in quality of life that may result from diagnosis and treatment. In 1988, the concept of early detection and curative radical therapy for prostate cancer was introduced in the Tyrol.

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