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Archive for the 'Lymphoma / Leukemia' Category

The Genetics Of Aging And Cancer Resistance

In the November 15th issue of G&D, Dr. Kenneth Dorshkind and colleagues at the David Geffen School of Medicine (UCLA) have identified two genes - p16(Ink4a) and Arf - that sensitize lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis. Hematopoiesis (the development of blood cells) entails two main pathways: myelopoiesis (the formation of the red and white myeloid cells) and lymphopoiesis (the formation of B- and T-cells).

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Researchers Aim To Over-stress Already Taxed Mantle Cell Lymphoma Cells

Cancer cells are already stressed by the fast pace they require to grow and spread and scientists believe a little more stress just may kill them. “Think about an assembly line in a factory that is working five times faster than normal,” said Dr. Kapil Bhalla, director of the Medical College of Georgia Cancer Center. “There is a lot of stress but you need workers to keep going. Some of them fall out, some get bent out of shape.

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Cell Therapeutics’ Pixantrone Phase III (EXTEND) Pivotal Trial Successful In Achieving Primary Endpoint

Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) announced that it achieved the primary efficacy endpoint of its phase III EXTEND (PIX301) trial of pixantrone (BBR2778) for patients with advanced, relapsed aggressive non-Hodgkin’s lymphoma (NHL) based on a preliminary intent to treat efficacy analysis.

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