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Archive for the 'Huntingtons Disease' Category

Structure Of Important Neurological Receptor Defined By Scripps Research Scientists

Oct 13th 2008Drug InformationHuntingtons Disease

Findings establish a platform to understand G protein-coupled receptors; may help in development of new class of Parkinson’s treatments Scientists from The Scripps Research Institute have determined the structure of an adenosine receptor that plays a critical role in a number of important physiological processes including pain, breathing, and heart function.

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Repligen Announces Publication Of Positive Results With Proprietary HDAC Inhibitor In Huntington’s Disease Model

Sep 30th 2008Drug InformationHuntingtons Disease

Repligen Corporation (Nasdaq: RGEN) reported publication of a preclinical study demonstrating that a novel histone deacetylase (HDAC) inhibitor improved disease symptoms in a transgenic animal model of Huntington’s disease. The study, led by scientists at The Scripps Research Institute, demonstrated that oral administration of the drug candidate to the mice after the onset of symptoms slowed the progression of disease.

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Scientists Create Disease-Specific Stem Cell Lines

Sep 8th 2008Drug InformationHuntingtons Disease

US researchers have found a way to produce immortal cell strains and tissue types from diseased patients by converting their cells into pluripotent stem cells with the same genetic errors. The new cell lines will enable scientists to investigate ten different genetic disorders like Parkinson’s, muscular dystrophy, and type 1 diabetes in the test tube instead of in the patient, a huge step forward compared to current methods.

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