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On June 10, 2008 the scientific journal Vaccine published a paper by the Massachusetts based biotech company Cure Lab, Inc., demonstrating that a protein sequence important in neurodegenerative Huntington’s disease can be safely used as a new generation of vaccine adjuvants.The major component of every vaccine is an antigen that elicits specific immunity to a particular virus, bacteria or even cancer cells.

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Kevin Harrington, a Bay Area native suffering from the effects of Huntington’s Disease, may have lost his mother, grandfather, great-grandfather and a great uncle to this tragic disease but he refuses to lose hope for a cure. So he organized the 2008 Mason-McDuffie Mortgage Invitational “Swinging to Cure Huntington’s Disease” golf tournament to be held at the Blackhawk Country Club on Monday, June 16th, 2008.

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The Huntington Study Group has launched a Phase III clinical trial, funded by the National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health [NIH]), to determine the effect of the maximum effective dosage of Coenzyme Q10 on cognitive function in individuals with Huntington’s Disease (HD). They will also examine the long-term safety of CoQ10.

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Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington’s disease. Emory University researchers engineered a virus to make an intracellular antibody or “intrabody” against huntingtin, the protein whose mutant forms poison the brain cells of people with Huntington’s.

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Research funded by the Wellcome Trust has provided a number of promising new drug targets for Huntington’s disease, a neurodegenerative disease. Scientists at the University of Cambridge have identified a number of candidate drugs to investigate further which encourage cells to “eat” the malformed proteins that lead to the disease.

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Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced that Sirtris Scientific Advisory Board Co-Chair Leonard P.

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Hoping to piece together the intricate series of interactions that lead to Huntington’s disease, Indiana University Bloomington scientists have determined the shape and structure of a binding site that may prove useful in combating the neurodegenerative disease.In the Feb.

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Working with fruit flies, researchers have discovered a new mechanism by which the abnormal protein in Huntington’s disease causes neurodegeneration. They have also manipulated the flies to successfully suppress that neurodegeneration, which they said suggests potential treatments to delay the onset and progression of the disease in humans.Juan Botas and colleagues published their findings in the January 10, 2008, issue of the journal Neuron, published by Cell Press.

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CombinatoRx, Incorporated (NASDAQ: CRXX) announced that it has received the Marjorie Guthrie Leadership Award from the Huntington’s Disease Society of America (HDSA) during their 40th Anniversary Guthrie Awards Dinner in New York City to benefit the Woody and Marjorie Guthrie Research fund. Alexis Borisy, President and CEO of CombinatoRx was present to accept the award. [click link for full article]

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MassGeneral Institute for Neurodegererative Disease (MIND) researchers have identified a compound that may lead to a treatment that could protect against the effects of Huntington’s Disease (HD). Their report, which will appear in the Proceedings of the National Academy of Sciences, describes how a small molecule called C2-8 appears to delay the loss of motor control and reduce neurological damage in a mouse model of the disorder. The study is receiving early online release. [click link for full article]

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