Researchers have identified a set of objective, validated measures for evaluating new treatments for Huntington’s disease (HD) in phase 2 and 3 clinical trials. According to the researchers, whose findings have been published Online first in The Lancet Neurology, the discovery should increase future new drug trial’s chances of success to delay onset and reduce […]
Filed under: Huntingtons Disease on December 4th, 2011 | No Comments »
According to results of the phase 3 MermaiHD trial published Online First in The Lancet Neurology, a unique drug (pridopidine) that stabilizes dopamine signaling in areas of the brain controlling movement and coordination in patients with Huntington’s disease (HD), a condition characterized by an imbalance in the signaling chemical dopamine, seems to be well tolerated […]
Filed under: Huntingtons Disease on November 13th, 2011 | No Comments »
Melatonin, best known for its role in sleep regulation, delayed the onset of symptoms and reduced mortality in a mouse model of Huntington’s disease, say researchers at the University of Pittsburgh School of Medicine and Harvard Medical School…
More: continued here
Filed under: Huntingtons Disease on October 13th, 2011 | No Comments »
Huntington’s disease is a devastating neurogenerative disorder that causes a progressive loss of functional capacity and reduced life span. It is an inherited condition caused by a mutant HTT gene…
More: continued here
Filed under: Huntingtons Disease on October 11th, 2011 | No Comments »
Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD). Morris White and colleagues, at Harvard Medical School, Boston, have now determined that modulating levels of the signaling protein Irs2 changes disease progression in a mouse model of HD…
More: continued here
Filed under: Huntingtons Disease on September 21st, 2011 | No Comments »
A new study of the brain’s master circadian clock - known as the suprachiasmatic nucleus, or SCN - reveals that a key pattern of rhythmic neural activity begins to decline by middle age. The study, whose senior author is UCLA Chancellor Gene Block, may have implications for the large number of older people who have […]
Filed under: Huntingtons Disease on July 20th, 2011 | No Comments »
UT Southwestern Medical Center researchers have identified compounds that appear to inhibit a signaling pathway in Huntington’s disease, a finding that may eventually lead to a potential drug therapy to help slow the progression of degenerative nerve disorders…
More: continued here
Filed under: Huntingtons Disease on June 25th, 2011 | No Comments »
Johns Hopkins researchers have identified a natural mechanism that might one day be used to block the expression of the mutated gene known to cause Huntington’s disease. Their experiments offer not an immediate cure, but a potential new approach to stopping or even preventing the development of this relentless neurodegenerative disorder…
More: continued here
Filed under: Huntingtons Disease on June 22nd, 2011 | No Comments »
Medical researchers may have uncovered a novel approach to treat an incurable and ultimately fatal neurodegenerative disease that affects hundreds of thousands of people…
More: continued here
Filed under: Huntingtons Disease on June 2nd, 2011 | No Comments »
McMaster University researchers have discovered a new drug target that may be effective at preventing the onset of Huntington’s disease, working much the same way heart medications slow the progression of heart disease and reduce heart attacks…
More: continued here
Filed under: Huntingtons Disease on May 30th, 2011 | No Comments »