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Medarex, Inc. (Nasdaq: MEDX) announced that it has initiated the Phase 2 clinical development program of MDX-1100, a fully human monoclonal antibody that targets CXCL10 (also known as IP-10), in ulcerative colitis (UC) and rheumatoid arthritis (RA). MDX-1100 could potentially treat UC and RA by suppressing the inflammatory process characteristic of these diseases.

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A tool with the potential to determine the level of tissue damage in patients with osteo-arthritis, sports injuries and other conditions affecting bone and cartilage is being developed by QUT researchersProfessor Oloyede said that the device, which he calls a “smarthroscope”, may be able to reduce the cost of surgery, eliminate unnecessary surgery, and could be useful in developing countries.

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A leading arthritis charity accused the government’s health rationing watchdog of ‘penny-pinching’ in its decision to refuse thousands of people the chance to try an alternative life-changing anti-TNF drug if a first does not work for them. ‘Anti-TNFs can slow down the progress of rheumatoid arthritis. We hear so much about NHS choice but patients and clinicians alike will be frustrated by the decision to limit treatment options in this way.

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A common, incurable joint disease, osteoarthritis (OA) is the leading cause of disability in elderly people. While nearly any joint can be affected, OA most often strikes the knee, particularly the inner aspect of the tibiofemoral joint. One source of stress on this vulnerable joint compartment is the knee adduction moment, an indication of weight placement while walking.

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Trubion Pharmaceuticals Inc. (Nasdaq: TRBN) announced that its partner, Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), has commenced patient dosing in the next Phase 2b clinical trial of TRU-015 in patients with rheumatoid arthritis (RA). In collaboration with Trubion, Wyeth Pharmaceuticals is developing TRU-015, SBI-087 and other CD20-directed products.

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Researchers at the University of New Hampshire Glycomics Center have helped identify a specific carbohydrate structure that confers anti-inflammatory activity to a glycoprotein antibody that could lead to improved treatment of autoimmune diseases like lupus or rheumatoid arthritis. The study, reported in a recent edition of the journal Science, was led by immunologist Jeffrey Ravetch of Rockefeller University.

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Along with age and injuries, obesity is a leading risk factor for osteoarthritis (OA), a painful and disabling joint disease. While excessive weight can aggravate the toll on almost any joint, obesity has been associated with a higher prevalence of hip OA and an increase in total hip arthroplasty (THA). Whether obese hip OA patients are more prone to postsurgical complications, however, remains open to debate and investigation, since the results of existing studies conflict.

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Tick bites generate fears of Lyme disease in every parent, but this study of 99 children finds that one of Lyme’s complications — arthritis — has a good prognosis. Researchers led by Robert Sundel, MD, a rheumatologist at Children’s, found that 77 percent of children were cured with less than 3 months of antibiotic treatment. The remainder were also ultimately relieved of their arthritis, though additional treatment (usually one month of intravenous antibiotics) was required.

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About half of US adults with diabetes also have arthritis, which appears to be a barrier, in addition to lack of time and being too busy with other things, because they are not sure what exercise is appropriate and they are concerned about aggravating joint pain and causing further damage. The researchers suggest health care providers pay special attention to arthritis-related barriers among diabetics who are not physically active.

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Painful foot problems suffered by people with arthritis are seriously neglected and are subject to huge and unacceptable regional variations, according to a team of foot care experts. Only a quarter of patients who need foot health care have adequate access to NHS services, and only half of all hospital rheumatology departments in the UK are able to access adequate basic foot care services for their patients.

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