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Applied NeuroSolutions, Inc. (OTC BB:APNS), a biotechnology Company focused on the development of products for the early diagnosis and treatment of Alzheimer’s disease (”AD”), today announced the achievement of a key milestone directed to a multi-product program to develop serum-based diagnostic tests for Alzheimer’s disease.

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Women over 90 are significantly more likely to have dementia than men of the same age, according UC Irvine researchers involved with the 90+ Study, one of the nation’s largest studies of dementia and other health factors in the fastest-growing age demographic. The researchers reviewed an analysis of 911 people enrolled in the 90+ Study. Of those, 45 percent of the women had dementia, as opposed to 28 percent of the men.

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As more adults age into the high-risk period for cognitive impairment, clinicians need simple and reliable methods to identify where they may have problems in everyday life that reveal underlying changes in the brain.

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Research in fruit flies has shown that enhancing the production of a protein called neprilysin can reduce the formation of plaques and neuron death associated with Alzheimer’s, at the expense of reducing the flies’ lifespan. The buildup of amyloid-beta protein plaques within the brain is a major hallmark of Alzheimer’s, and one that is believed to contribute to disease progression.

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Scientists have long questioned whether the abundant amounts of amyloid plaques found in the brains of patients with Alzheimer’s actually caused the neurological disease or were a by-product of its progress. Now, using new research techniques, scientists have shown that a two-molecule aggregate (or dimer) of beta-amyloid protein fragments may play a role in initiating the disease.

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Health Minister Ivan Lewis outlined proposals to improve the quality of dementia care and provide more help for people with dementia, as he launched a consultation on the first ever National Dementia Strategy.

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Researchers have discovered the second, strong genetic risk factor for developing late-onset Alzheimer’s disease, according to a new report in the June 27th issue of the journal Cell, a Cell Press publication. The newly discovered gene, which previously had no known function, is predominantly active in a region of the brain that is hit early in the disease, where it acts as a channel for calcium, they show.

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Yesterday was a landmark day for people with dementia and their carers, as the government recognises dementia as a national priority. Dementia is a devastating condition caused by diseases of the brain, yet only a third of people ever receive a diagnosis and families are often left to cope alone until they reach crisis point. It’s time to drag dementia care out of the dark ages and change the way we treat some of our most vulnerable older people.

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An international group of scientists found that a new gene called calcium homeostasis modulator 1 (CALHM1), with a previously unknown function, is linked to late-onset Alzheimer’s Disease making this the second discovery of a strong genetic risk factor for the disease.

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Children with lower IQs are more likely decades later to develop vascular dementia than children with high IQs, according to research published in the June 25, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. The most common type of dementia after Alzheimer’s disease, vascular dementia occurs when blood flow to the brain is impaired.

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