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The brain’s serotonergic system plays an important role in alcohol preference and consumption. New findings show that specific DNA sequence variations of the serotonin transporter gene can influence drinking intensity among alcohol-dependent individuals. The brain’s serotonergic system plays an important role in alcohol preference and consumption. The serotonin transporter gene (SLC6A4), in particular, may regulate a person’s propensity for severe drinking.

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Mathematical models resolve controversy over nicotine addiction Increased use of computers to create predictive models of human disease is likely following a workshop organised by the European Science Foundation (ESF), which urged for a collaborative effort between specialists in the field. Human disease research produces an enormous amount of data from different sources such as animal models, high throughput genetic screening of human tissue, and in vitro laboratory experiments.

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While the physiological damage and social havoc created by alcohol abuse and dependency are well-known, it is also true that light-to-moderate drinking has certain health benefits. This mini-review summarizes a roundtable discussion held at the July 2007 annual meeting of the Research Society on Alcoholism in Chicago, Illinois. Results will be published in the February 2009 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

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