Aminoguanidine: An Attractive Line As A Multi-Modal Avenue To Overcome Tumor

Aminoguanidine is a compound that exerts multiple biological actions. Aminoguanidine has well described antioxidant properties and is also an inhibitor of nitric oxide synthases, the enzymes that produce nitric oxide. The nitric oxide molecule has been implicated in different biological processes associated with both survival and cell death. In vitro, nitric oxide exhibits cytostatic or cytotoxic effects in cancer cells according to its concentration within the tumor microenvironment.

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Filed under: Biology on March 11th, 2009