Trial Establishes New Data Regarding Safety Of Artemisinin Combination Therapy For Pregnant Women With Malaria

A trial conducted in northwest Thailand has found that it is safe to use artemisinin combination therapy (ACT) to treat pregnant women with malaria, but that efficacy is inferior to single-drug artesunate treatment. The study, published in next week’s PLoS Medicine, suggests that the ACT evaluated in the trial, artemether-lumefantrine (AL), may have lower efficacy because drug concentrations were seen to be reduced during pregnancy.

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Filed under: Clinical Trials on January 3rd, 2009