Activating The Lung’s Antioxidant Defense By Targeting Nrf2 Inhibits The Development Of Emphysema

Using a molecule similar to one found in an experimental cancer drug, researchers at the Johns Hopkins Bloomberg School of Public Health demonstrated that activation of a key component of the lung’s antioxidant defense system, Nrf2, can prevent emphysema in mice. The researchers believe that activation of Nrf2 could be a novel target for therapies to prevent chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic bronchitis.

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Filed under: Genetics on January 3rd, 2009