Response To HIV-Like Virus Improved, Survival Prolonged By Blocking Immune Inhibitor In Monkey Model

By blocking PD-1 (programmed death-1), an immune receptor molecule known to inhibit the immune response to chronic viral infections, scientists have safely and significantly reduced the plasma viral load and also prolonged survival of rhesus macaque monkeys severely infected with simian immunodeficiency virus (SIV), the nonhuman primate version of human immunodeficiency virus (HIV).

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Filed under: Biology on December 11th, 2008