Prioritization Of Disease-Associated SNPs Improved By New Approach

The more often a gene is differentially expressed, the more likely it is to contain disease-associated DNA variants. Research published in BioMed Central’s open access journal Genome Biology shows how a list of SNPs in genes that are repeatedly implicated across many publicly-available gene expression microarray experiments (so-called, ‘fitSNPs’), based on differential expression rates, can be used to successfully prioritize candidate genes for further research.

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Filed under: Genetics on December 6th, 2008