UCLA’s Jonsson Cancer Center Scientists Identify Signaling Pathway Driving A Deadly Sub-Type Of Breast Cancer

An intra cellular pathway not previously linked to breast cancer is driving a sub-type of the disease that is highly lethal and disproportionately over-represented in African American women. The pathway regulates how cells identify and destroy proteins and represents a class of genes called proteasome targeting complexes. The work shows that basal cancer cells degrade the tumor suppressor gene p27 by making a new type of proteasome targeting complex.

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Filed under: Breast Cancer on November 21st, 2008