Normal Mouse Embryonic Heart Development Disrupted By Loss Of The Protein Target Of Lithium
Oct 3rd 2008Drug InformationCardiovascular
Individuals with bipolar disorder are usually treated with ‘mood stabilizing’ drugs, one of which is lithium - an inhibitor of GSK-3 proteins. As new drugs that are more powerful inhibitors of GSK-3 are under development despite controversial studies suggesting a link between lithium therapy and congenital heart defects, Thomas Force and colleagues, at Thomas Jefferson University, Philadelphia, set out to determine whether GSK-3 proteins are important for heart development in mice.
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