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Molecular Circuits For Associative Learning In Single-celled Organisms

Can you teach old bacteria new tricks? We present a model of a gene circuit that could be made using synthetic biology to allow bacteria to learn. Pavlov’s dog learned to associate the sound of a bell with the smell of food. Our circuit allows a bacterium to learn when a chemical consistently precedes a harmful one, and thus to anticipate and predict the harmful chemical by synthesising a therapeutic gene product even before the harmful chemical appears.

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