Dynamics Of Conserved Waters In Human HSP 90: Implications For Drug Design

Water is known to be a potential mediator between a drug and its receptor but to what extent must it be considered to be essentially part of the active site and should a putative drug try to expel it. Here we probe the dynamic behaviour of several water molecules that are predicted to persist in the active site of a potential anti-cancer site.

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Filed under: Biology on October 3rd, 2008