HBV infection remains a major health problem in the world. Several data have revealed that lamivudine can efficiently promote the treatment of hepatitis B. However, a long-term treatment of lamivudine leads to the emergence of lamivudine-resistant mutants (YMDD mutants), which hampers the anti-HBV therapy. Therefore, researches related to HBV lamivudine-resistant mechanism has been of great significance.

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