Seizure-Induced AMPA Receptor Phosphorylation, Journal Of Neuroscience

Seizures in neonates are usually caused by hypoxia and can increase risk of later epilepsy and cognitive impairment. Rakhade et al. induced hypoxic seizures in early postnatal rats to identify molecular changes that increase seizure susceptibility. Seizures increased the amplitude and frequency of miniature and spontaneous EPSCs mediated by AMPA receptors (AMPARs) within 1 h.

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Filed under: Epilepsy on August 11th, 2008