Continuous Sivelestat Sodium Hydrate Infusion Averts Lipopolysaccharide-Induced Intestinal Paralysis And Hypotension In Conscious Guinea-Pigs

This study examined the effects of continuous administration of sivelestat sodium hydrate (sivelestat) on guinea pigs induced with intestinal paralysis and hypotension. Findings suggest that sivelestat - a neutrophil elastase (NE) inhibitor- can effectively reduce intestinal dysfunction and attenuate hypotension. NE is a protease released in response to inflammation and is believed to trigger acute respiratory distress syndrome (ARDS) and ARDS-related lung injury.

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Filed under: Clinical Trials on July 26th, 2008