Continuous Sivelestat Sodium Hydrate Infusion Averts Lipopolysaccharide-Induced Intestinal Paralysis And Hypotension In Conscious Guinea-Pigs
This study examined the effects of continuous administration of sivelestat sodium hydrate (sivelestat) on guinea pigs induced with intestinal paralysis and hypotension. Findings suggest that sivelestat - a neutrophil elastase (NE) inhibitor- can effectively reduce intestinal dysfunction and attenuate hypotension. NE is a protease released in response to inflammation and is believed to trigger acute respiratory distress syndrome (ARDS) and ARDS-related lung injury.
More: continued here