Immunotherapy With Leukemia-cell-derived Heat Shock Protein 70 Triggers Induction Of Leukemia-specific Antibodies

Even after chemotherapies and stem cell transplants, relapses still occur in leukemia patients. This study established a mouse model after bone marrow transplant and found that the immunization of mice with leukemia-cell-derived heat shock protein 70 (HSP) induced leukemia-specific immunities and prolonged their survival. The tumor-derived-HSP binds the tumor-specific antigenic peptides, making it an effective cancer vaccination.

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Filed under: Cancer on July 25th, 2008