Splenic Ellipsoids Might Be Significant In The Early Development Of AA Amyloidosis

During the course of her PhD studies, Randi Sorby demonstrated that ellipsoids, small filtering units for blood in the spleen, might be significant in the development of AA amyloidosis. AA amyloidosis is a potential complication of chronic inflammation or infection, for example, rheumatoid arthritis and tuberculosis, and is characterised by systematic deposition of protein fibrils in the tissues of organs such as the spleen and liver.

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Filed under: Endocrinology on June 30th, 2008