Aggressive Subclass Of Prostate Cancer May Be Driven By Estrogen Signaling - May 27 JNCI

Aggressive prostate cancers that harbor a particular gene fusion are a distinct molecular subtype of the disease and their growth may be regulated by estrogen signaling.Prostate cancers that carry the TMPRSS2-ERG gene fusion, which links the regulatory region of one gene to the protein-coding region of another, tend to be aggressive. The molecular mechanism by which the fusion gene impacts pathogenesis has been unknown.Mark Rubin, M.D.

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Filed under: Endocrinology on June 1st, 2008