Can Pathological Techniques Help Identify Primary Colorectal Signet Ring Cell Carcinoma?

Primary colorectal signet ring cell carcinoma is a rare but distinctive malignancy of the large bowel. More than 96% of signet ring cell carcinomas arise in the stomach, with the rest arising from other primary organs. Therefore, a secondary infiltration or metastasis to the colon and rectum must be excluded before a definite diagnosis of primary colorectal signet ring cell carcinoma can be established.

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