Sorting Of CEA Modulated By Cholesterol, Implications For Inflammatory Bowel Disease

In polarized Caco-2 cells, cholesterol was depleted by a combination of synthesis inhibition and plasma membrane extraction with complexing agents. This led to an increased sorting of CEA to the basolateral surface. Interestingly, polarity was not significantly affected by this approach. The association of CEA to lipid rafts, cholesterol, and sphingolipid-enriched microdomains was inhibited in parallel.This study, performed by a team led by Dr.

More: continued here

Filed under: Cholesterol on May 15th, 2008