Presence Of Amphiregulin Autocrine-loop Predicts Sensitivity Of EGFR Wild Type Cancers To Gefitinib And Cetuximab

Researchers have discovered a biomarker in epidermal growth factor receptor (EGFR) wild-type non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) cell lines. This so-called amphiregulin autocrine loop appears to predict response to the targeted therapies gefitinib and cetuximab.

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Filed under: Cancer on April 17th, 2008