Genmab A/S - Company Announcement: Novel Insights Into HuMax-EGFr Mechanisms Of Action Published In PNAS

Summary: Genmab has announced that HuMax-EGFr (zalutumumab) inhibits epidermal growth factor receptor signaling by locking epidermal growth factor receptor (EGFr) molecules into a very compact, inactive conformation. The flexibility of the EGFr is central to its role in signaling, and binding of HuMax-EGFr (zalutumumab) results in effective inhibition of cancer cell growth.

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Filed under: Endocrinology on April 17th, 2008