Polyglutamine Genes Interact To Modulate The Severity And Progression Of Neurodegeneration In Drosophila

Six forms of spinal cerebellar ataxia (SCA1, 2, 3, 6, 7, and 17) are caused by dominant mutations in the respective genes. Patients suffering from these different forms of SCA have similar symptoms of progressive adult-onset neurodegeneration, and the same causative mutation, a CAG repeat expansion encoding an expanded run of polyglutamine.

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Filed under: Genetics on February 12th, 2008