Inflammation-Induced Colon Cancer Stopped In Its Tracks By TNF-Alpha Antagonist
Jan 29th 2008Drug InformationColorectal Cancer
Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data generated by Naofumi Mukaida and colleagues at Kanazawa University, Japan, identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice in which inflammation of the bowel was induced by administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion.
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