Beyond The Abstract - Maternal Smoking During Pregnancy Specifically Reduces Human Fetal Desert Hedgehog Gene Expression During Testis Development
Jan 29th 2008Drug InformationSmoking / Quit Smoking
UroToday.com - In this article, published in the Journal of Clinical Endocrinology and Metabolism, Fowler and colleagues report that continued cigarette smoking by women with normally progressing pregnancies nearly halves Desert hedgehog (DHH) gene expression in the testes of second trimester fetuses. Expression of 29 other key testis genes and testis cell numbers were not significantly affected but circulating fetal testosterone tended to be reduced if the mother smoked.
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