Uroplakin III-Delta4 Messenger RNA As A Promising Marker To Identify Nonulcerative Interstitial Cystitis

UroToday.com- It is widely accepted that the apical surface of mammalian urothelium is covered by numerous rigid-appearing plaques that contribute to the specialized permeability barrier. These plaques contain 4 major integral membrane proteins: uroplakin 1a, uroplakin 1b, uroplakin II, and uroplakin III. Animal knockout models without uroplakin II or III have a greatly decreased number and average size of apical plaques and develop vesicoureteral reflux and hydronephrosis.

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Filed under: Urology on January 13th, 2008