Enhanced Adenosine Triphosphate Release From The Urothelium Of Patients With Painful Bladder Syndrome: A Possible Pathophysiological Explanation

UroToday.com- Adenosine triphosphate (ATP) has been increasingly recognized as an important sensory neurotransmitter. A number of studies support the idea that mechanical stimuli can evoke ATP release from epithelial cells lining tubes or sacs, such as the bladder. Release of ATP may activate P2X receptors on suburothelial sensory nerves and thus may have an important role in sensory functions, such as nociception.

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Filed under: Neurology / Neuroscience on January 13th, 2008