Beyond The Abstract Clusterin Isoforms Differentially Affect Growth And Motility Of Prostate Cells: Possible Implications In Prostate Tumorigenesis

BERKELEY, CA (UroToday.com) - Despite the considerable attention that the Clusterin (CLU) gene has received from many research laboratories, its possible biological role is still debated. CLU is often considered an “enigmatic” gene, also because of conflicting or sometimes confusing hypotheses based on experimental results which were somehow contradictory (i.e. Is CLU up- or down-regulated in prostate cancer? When highly expressed, it exerts a pro- or an anti-apoptotic role?).

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Filed under: Prostate on January 12th, 2008