Possible Link Between INOS Expression, Chronic Biliary Inflammation And Malignant Transformation

It is well known that chronic biliary inflammation is a risk factor for biliary carcinogenesis. However, the molecular mechanisms of biliary carcinogenesis as a consequence of chronic biliary inflammation remain unclear.Inducible nitric oxide synthase (iNOS) is induced in inflamed tissues and generates large amounts of nitric oxide (NO) that can promote mutagenic changes in DNA through DNA oxidization and protein nitrosylation. [click link for full article]

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Filed under: Biology on December 20th, 2007