Persistent Hypocalcemia Induced By Zoledronic Acid In A Patient With Androgen Independent Prostate Cancer And Bone Metastases

UroToday.com - Many physicians are aware of well-publicized side effects of intravenous bisphosphonates such as renal dysfunction and osteonecrosis of the jaw. Hypocalcemia associated with bisphosphonate therapy is relatively rare but is severe in about 2% of cases1. Bisphosphonates such as zoledronate lower serum calcium by inhibiting osteoclast-mediated bone resorption. [click link for full article]

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Filed under: Prostate on December 2nd, 2007