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Clues To Human Longevity May Result From A Longer-Living, Healthier Mouse Model

A study by scientists at UCL (University College London) shows that mice lacking the insulin receptor substrate (IRS)-1 are more resistant to ageing than normal mice. The research adds to a growing body of work showing the importance of insulin signalling pathways as an ageing mechanism in mammals — and potentially humans.The team studied ‘knock-out’ mice engineered to lack either insulin receptor substrate (IRS)-1 or -2. [click link for full article]

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