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Proper formation of the proteins that power heart and skeletal muscle seems to rely on a precise concentration of a “chaperone” protein known as UNC-45, according to a new study.This basic discovery may have important implications for understanding and eventually treating heart failure and muscle wasting elsewhere in the body resulting from burns, brain trauma, diabetes, cancer and the effects of aging, the senior author of the paper said. [click link for full article]

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Alimera Sciences, a privately held ophthalmic pharmaceutical company, and global drug delivery company pSivida Limited (Nasdaq: PSDV, ASX: PSD, Xetra: PSI) today announced that enrollment for their Phase 3 global clinical trial, the FAME(TM) (Fluocinolone Acetonide in Diabetic Macular Edema) Study has exceeded 50 percent. FAME is a double masked, randomized, multi-center study that will follow approximately 900 patients in the U.S., Canada, Europe and India for 36 months. [click link for full article]

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The death of Rep. Juanita Millender-McDonald, a seven-term congresswoman from southern California, on Saturday, serves as a sober reminder for women of the dangers of cancer, according to the Society for Women’s Health Research, a Washington, D.C. based advocacy organization focused on health differences between women and men. “Our sympathies are with the family of Rep. Millender-McDonald,” said Sherry Marts, Ph.D. [click link for full article]

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A special report in The New England Journal of Medicine concludes that the sharp decline in breast-cancer incidence in 2003, followed by a relative stabilization at a lower rater in 2004, is most likely related to the first report of the Women’s Health Initiative (WHI) (JAMA 2002; 288:321-333. Risks and benefits of estrogen plus progestin in healthy postmenopausal women) and the ensuing drop in hormone-replacement therapy among postmenopausal women. [click link for full article]

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Execution by lethal injection may cause death by asphyxiation, and prisoners being executed may be conscious and may experience pain, claim the authors of a new study published this week in PLoS Medicine. Leonidas Koniaris and colleagues from the University of Miami assessed data from two US states that release information on executions together with previously published work on the drugs used in the protocols for lethal injections. [click link for full article]

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University of Alabama at Birmingham (UAB) psychologists have developed an animal model for the binge eating disorder, which affects an estimated one in 20 Americans. The Sprague-Dawley rat model could lead to the identification of physiological mechanisms that distinguish different types of eating disorders and to the creation of new, targeted drug therapies. [click link for full article]

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Inner city children from poor families are much more likely to seek emergency care for asthma than their more affluent peers, finds research published ahead of print in Thorax. But the reasons are not the expected culprits of damp housing, overcrowding, or living with a smoker, finds the study. Rather, parents feeling panicky, previous outpatient visits, and a belief that emergency care would mean faster treatment, explain the figures, say the authors. [click link for full article]

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When does the wait time for cataract surgery cross over from being inconvenient to affecting health and quality of life? Dr. William Hodge and colleagues report on their systematic review of studies that assessed the relation between wait times for cataract surgery and patient outcomes. They found that patients who received cataract surgery within 6 weeks of surgical booking experienced better visual and quality-of-life outcomes and experienced fewer adverse events (e.g. [click link for full article]

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Eating regularly in some fast-food chain outlets is unsafe in many parts of the world, top Danish research experts warn today. Food quality and portion sizes need to be improved dramatically, according to the Copenhagen University research group, led by Prof Steen Stender, who found major variations in the quality of products offered by the same chains across 35 countries. [click link for full article]

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America’s Health Insurance Plans on Thursday asked Congress to establish a new agency that would compare the cost and effectiveness of medical treatments as part of a series of recommendations to reduce health care costs, CongressDaily reports (CongressDaily, 4/20). [click link for full article]

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